Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor.

@article{Macfarlan2005HumanTI,
  title={Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor.},
  author={Todd Macfarlan and Sara N. Kutney and Brian J Altman and Rebecca Montross and Jiujiu Yu and Debabrata Chakravarti},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 8},
  pages={
          7346-58
        }
}
The identities of signal transducer proteins that integrate histone hypoacetylation and transcriptional repression are largely unknown. Here we demonstrate that THAP7, an uncharacterized member of the recently identified THAP (Thanatos-associated protein) family of proteins, is ubiquitously expressed, associates with chromatin, and represses transcription. THAP7 binds preferentially to hypoacetylated (un-, mono-, and diacetylated) histone H4 tails in vitro via its C-terminal 77 amino acids… CONTINUE READING
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