Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

  title={Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation},
  author={Hania K{\'e}bir and Katharina Kreymborg and Igal Ifergan and Aurore Dodelet-Devillers and Romain Cayrol and Monique Bernard and Fabrizio Giuliani and Nathalie Arbour and Burkhard Becher and Alexandre Prat},
  journal={Nature Medicine},
TH17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, TH17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4… CONTINUE READING
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