Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.

@article{Fu2003HumanTV,
  title={Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.},
  author={De-xue Fu and Yu-Liang Kuo and Bao-ying Liu and Kuan-Teh Jeang and Chou-Zen Giam},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 3},
  pages={
          1487-93
        }
}
I-kappa B kinase (IKK) is a serine/threonine kinase that phosphorylates I-kappa B alpha and I-kappa B beta and targets them for polyubiquitination and proteasome-mediated degradation. IKK consists of two highly related catalytic subunits, alpha and beta, and a regulatory gamma subunit, which becomes activated after serine phosphorylation of the activation loops of the catalytic domains. The human T-lymphotropic retrovirus type-I trans-activator, Tax, has been shown to interact directly with IKK… CONTINUE READING

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