Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

@article{Maher2002HumanTC,
  title={Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR$\zeta$ /CD28 receptor},
  author={J. Maher and R. Brentjens and Gertrude Gunset and I. Rivi{\`e}re and M. Sadelain},
  journal={Nature Biotechnology},
  year={2002},
  volume={20},
  pages={70-75}
}
Artificial receptors provide a promising approach to target T lymphocytes to tumor antigens. However, the receptors described thus far produce either an activation or a co-stimulatory signal alone, thus limiting the spectrum of functions accomplished by the genetically modified cells. Here we show that human primary T lymphocytes expressing fusion receptors directed to prostate-specific membrane antigen (PSMA) and containing combined T-cell receptor-ζ (TCRζ), and CD28 signaling elements… Expand
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