Human T cells that are able to produce IL-17 express the chemokine receptor CCR6.

@article{Singh2008HumanTC,
  title={Human T cells that are able to produce IL-17 express the chemokine receptor CCR6.},
  author={Satya Prakash Singh and Hongwei H Zhang and John F. Foley and Michael N. Hedrick and Joshua M Farber},
  journal={Journal of immunology},
  year={2008},
  volume={180 1},
  pages={214-21}
}
Some pathways of T cell differentiation are associated with characteristic patterns of chemokine receptor expression. A new lineage of effector/memory CD4+ T cells has been identified whose signature products are IL-17 cytokines and whose differentiation requires the nuclear receptor, RORgammat. These Th17 cells are critical effectors in mouse models of autoimmune disease. We have analyzed the association between chemokine receptor expression and IL-17 production for human T cells. Activating… CONTINUE READING
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