Human T-cell tumours containing chromosome 14 inversion or translocation with breakpoints proximal to immunoglobulin joining regions at 14q32.

@article{MENGLEGAW1987HumanTT,
  title={Human T-cell tumours containing chromosome 14 inversion or translocation with breakpoints proximal to immunoglobulin joining regions at 14q32.},
  author={Laurel MENGLE-GAW and Huntington F. Willard and C I Edvard Smith and Lennart Hammarstr{\"o}m and Peter S. Fisacher and Paul D. Sherrington and George Carchedi Lucas and Peter Walker Thompson and Richard D. Baer and Terence H Rabbitts},
  journal={The EMBO journal},
  year={1987},
  volume={6 8},
  pages={
          2273-80
        }
}
T-cell tumours are frequently found to carry an inversion of chromosome 14 (inv(14)) (q11;q32) or more rarely a chromosome 14 translocation t(14;14) with the same cytogenetic breakpoints (q11;q32). We have examined the molecular junctions of an inv(14) and a translocation t(14;14) using T-cell receptor (TCR) alpha joining (J) region probes. Both of these chromosomal abnormalities have breakpoints within the TCR J alpha locus at 14q11 and both have breakpoints which are proximal (i.e. on the… CONTINUE READING
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