Human T cell responses to Japanese encephalitis virus in health and disease

  title={Human T cell responses to Japanese encephalitis virus in health and disease},
  author={Lance Turtle and Tanushka Bali and Gemma Buxton and Savita Chib and Sajesh Chan and Mohammed Soni and Mohammed Tabarak Hussain and Heather L Isenman and Prachi Rahul Fadnis and Manjunatha Muniswamappa Venkataswamy and Vishali Satishkumar and Penny Lewthwaite and Ayako Kurioka and Srinivasa Krishna and Meenakshi Shankar and Riyaz Akhtar Ahmed and Ashia Begum and Vasanthapuram Ravi and Anita Desai and Sutee Yoksan and Stefan Fernandez and Christian B Willberg and Henrik N. Kloverpris and Christopher Conlon and Paul Klenerman and Vijaya Satchidanandam and Tom Solomon},
  booktitle={The Journal of experimental medicine},
Japanese encephalitis (JE) virus (JEV) is an important cause of encephalitis in children of South and Southeast Asia. However, the majority of individuals exposed to JEV only develop mild symptoms associated with long-lasting adaptive immunity. The related flavivirus dengue virus (DENV) cocirculates in many JEV-endemic areas, and clinical data suggest cross-protection between DENV and JEV. To address the role of T cell responses in protection against JEV, we conducted the first full-breadth… CONTINUE READING
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