Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures.

@article{Hoffman1992HumanTL,
  title={Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures.},
  author={Paul M. Hoffman and Suhayl Dhib-Jalbut and Judy A. Mikovits and Douglas Robbins and Angel L Wolf and Gregory K. Bergey and Nancy Lohrey and O S Weislow and Francis W. Ruscetti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 24},
  pages={11784-8}
}
The pathogenesis of progressive spastic paraparesis [HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)], a serious consequence of human T-cell leukemia virus type I (HTLV-I) infection, is unclear. T and B lymphocytes can be naturally infected by HTLV-I, but the susceptibility to HTLV-I infection of other cell types that could contribute to the pathogenesis of HAM/TSP has not been determined. We found that a human monocyte cell line (THP-1), primary human peripheral blood… CONTINUE READING
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