Human T-cell leukemia virus type I Tax protein represses gene expression through the basic helix-loop-helix family of transcription factors.

@article{Uittenbogaard1994HumanTL,
  title={Human T-cell leukemia virus type I Tax protein represses gene expression through the basic helix-loop-helix family of transcription factors.},
  author={M N Uittenbogaard and Allison P Armstrong and Anne Chiaramello and Jennifer K. Nyborg},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 36},
  pages={22466-9}
}
The human T-cell leukemia virus type I (HTLV-I) oncoprotein Tax is a potent activator of viral and cellular gene transcription. Tax does not bind DNA directly but utilizes cellular transcription factors to mediate activation. In this report, we examine the role of the basic helix-loop-helix (bHLH) proteins in Tax deregulation of gene expression, as these proteins play a critical role in progression through the cell cycle and have been implicated in neoplastic disease. We show that the bHLH… CONTINUE READING