Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency.

@article{Beraud1994HumanTL,
  title={Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency.},
  author={Christophe Beraud and Shao-cong Sun and Parham A Ganchi and Dean W. Ballard and Warner C. Greene},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 2},
  pages={1374-82}
}
Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of the adult T-cell leukemia, an aggressive and often fatal malignancy of activated human CD4 T cells. HTLV-I encodes an essential 40-kDa protein termed Tax that not only transactivates the long terminal repeat of this retrovirus but also induces an array of cellular genes. Tax-mediated transformation of T cells likely involves the deregulated expression of various cellular genes that normally regulate lymphocyte growth produced… CONTINUE READING

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