Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAs.

@article{Kusuhara1999HumanTL,
  title={Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAs.},
  author={Koichi Kusuhara and Mandy Anderson and Sherrie M Pettiford and Patrick L. Green},
  journal={Journal of virology},
  year={1999},
  volume={73 10},
  pages={8112-9}
}
The human T-cell leukemia virus (HTLV) Rex protein is essential for efficient expression of the viral structural and enzymatic gene products. In this study, we assessed the role of the HTLV-2 rex gene in viral RNA expression and Gag protein production. Following transfection of human JM4 T cells with wild-type and rex mutant full-length proviral constructs, PCR was used for semiquantitative analysis of specific viral RNA transcripts. In the presence of Rex, the total amount of steady-state… CONTINUE READING

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