Human T-cell leukemia virus type 1 envelope glycoprotein gp46 interacts with cell surface heparan sulfate proteoglycans.

@article{Pin2003HumanTL,
  title={Human T-cell leukemia virus type 1 envelope glycoprotein gp46 interacts with cell surface heparan sulfate proteoglycans.},
  author={Josefina D. Pi{\~n}{\'o}n and Per Johan Klasse and Sushma R Jassal and Sandy Y Welson and Jonathan Weber and David W. Brighty and Quentin J Sattentau},
  journal={Journal of virology},
  year={2003},
  volume={77 18},
  pages={9922-30}
}
The major receptors required for attachment and entry of the human T-cell leukemia virus type 1 (HTLV-1) remain to be identified. Here we demonstrate that a functional, soluble form of the HTLV-1 surface envelope glycoprotein, gp46, fused to an immunoglobulin Fc region (gp46-Fc) binds to heparan sulfate proteoglycans (HSPGs) on mammalian cells. Substantial binding of gp46-Fc to HeLa and Chinese hamster ovary (CHO) K1 cells that express HSPGs was detected, whereas binding to the sister CHO lines… CONTINUE READING