Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a.

@article{Low1997HumanTL,
  title={Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a.},
  author={K G Low and Lydia F. Dorner and Daniel Fernando and Jason Grossman and Kuan Teh Jeang and Michael Comb},
  journal={Journal of virology},
  year={1997},
  volume={71 3},
  pages={1956-62}
}
The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein causes cellular transformation by deregulating important cellular processes such as DNA repair, transcription, signal transduction, proliferation, and growth. Although it is clear that normal cell cycle control is deregulated during HTLV-1-induced cellular transformation, the effects of Tax on cell cycle control are not well understood. Flow cytometric analyses of human T cells indicate that cell cycle arrest in late G1, at or… CONTINUE READING

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