Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300.

@article{Zhang2008HumanTL,
  title={Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300.},
  author={Jing Zhang and Osamu Yamada and Kenji Kawagishi and Hiromasa Araki and Shoji Yamaoka and Toshio Hattori and Kunitada Shimotohno},
  journal={Virology},
  year={2008},
  volume={379 2},
  pages={306-13}
}
We describe here Tax protein of human T-cell leukemia virus type 1 (HTLV-1) as an interferon (IFN)-alpha antagonist counteracting the transactivation function of IFN-stimulated gene factor 3 (ISGF3). Co-expression of Tax, but not the Tax mutant unable to bind to CBP, significantly inhibited the reporter gene expression directed by IFN-stimulated regulatory elements, despite that the formation of DNA-binding ISGF3 complex was unaffected. Gene activation induced by STAT2 transcription domain was… CONTINUE READING
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