Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells.

@article{Jones2006HumanTL,
  title={Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells.},
  author={Kathryn S. Jones and Kazunori Fugo and Cari Petrow-Sadowski and Ying K. Huang and Daniel C. Bertolette and Ivonne Lisinski and Samuel W. Cushman and Steven Jacobson and Francis W. Ruscetti},
  journal={Journal of virology},
  year={2006},
  volume={80 17},
  pages={8291-302}
}
Studies using adherent cell lines have shown that glucose transporter-1 (GLUT-1) can function as a receptor for human T-cell leukemia virus type 1 (HTLV). In primary CD4(+) T cells, heparan sulfate proteoglycans (HSPGs) are required for efficient entry of HTLV-1. Here, the roles of HSPGs and GLUT-1 in HTLV-1 and HTLV-2 Env-mediated binding and entry into primary T cells were studied. Examination of the cell surface of activated primary T cells revealed that CD4(+) T cells, the primary target of… CONTINUE READING

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