Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

  title={Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation},
  author={Masao Matsuoka and K T Jeang},
  journal={Nature Reviews Cancer},
It has been 30 years since a 'new' leukaemia termed adult T-cell leukaemia (ATL) was described in Japan, and more than 25 years since the isolation of the retrovirus, human T-cell leukaemia virus type 1 (HTLV-1), that causes this disease. We discuss HTLV-1 infectivity and how the HTLV-1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage. We also explore the contribution of a newly discovered protein and RNA on the HTLV-1… CONTINUE READING
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