Human T-Lymphotropic Virus-1 Visualized at the Virological Synapse by Electron Tomography

Abstract

Human T-lymphotropic virus 1 (HTLV-1) is transmitted directly between cells via an organized cell-cell contact called a virological synapse (VS). The VS has been studied by light microscopy, but the ultrastructure of the VS and the nature of the transmitted viral particle have remained unknown. Cell-free enveloped virions of HTLV-1 are undetectable in the… (More)
DOI: 10.1371/journal.pone.0002251

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