Human Stx2-specific monoclonal antibodies prevent systemic complications of Escherichia coli O157:H7 infection.

@article{Mukherjee2002HumanSM,
  title={Human Stx2-specific monoclonal antibodies prevent systemic complications of Escherichia coli O157:H7 infection.},
  author={Jean Margreth Reviewer Mukherjee and Kerry Chios and Dianne M. Fishwild and D. Wesley Hudson and Susan C. O'Donnell and Stephen M. Rich and Arthur Donohue-Rolfe and Saul Tzipori},
  journal={Infection and immunity},
  year={2002},
  volume={70 2},
  pages={
          612-9
        }
}
Hemolytic-uremic syndrome (HUS) is a serious complication predominantly associated with infection by enterohemorrhagic Escherichia coli (EHEC), such as E. coli O157:H7. EHEC can produce Shiga toxin 1 (Stx1) and/or Shiga toxin 2 (Stx2), both of which are exotoxins comprised of active (A) and binding (B) subunits. In piglets and mice, Stx can induce fatal neurological symptoms. Polyclonal Stx2 antiserum can prevent these effects in piglets infected with the Stx2-producing E. coli O157:H7 strain… CONTINUE READING
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