Human Stiff person syndrome IgG-containing high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats.

@article{Hansen2013HumanSP,
  title={Human Stiff person syndrome IgG-containing high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats.},
  author={Niels Eilif Hansen and Benedikt Gr{\"u}newald and Andreas Weishaupt and Maria Nandini Colaço and Klaus Viktor Toyka and Claudia Sommer and Christian Geis},
  journal={Experimental neurology},
  year={2013},
  volume={239},
  pages={202-9}
}
Stiff person syndrome (SPS) is an autoimmune CNS disorder characterized by muscle rigidity, spasms and anxiety. The majority of patients have high-titer autoantibodies (ab) against glutamate decarboxylase (GAD65). A pathogenic role of SPS-associated IgG with ab against GAD65 has been shown for anxiety-like behavior but not for the core motor signs. We repetitively injected the purified IgG fraction of an SPS patient with severe motor impairment but without anxious comorbidity containing high… CONTINUE READING