Human Stanniocalcin-1 Suppresses Angiotensin II-Induced Superoxide Generation in Cardiomyocytes through UCP3-Mediated Anti-Oxidant Pathway

@inproceedings{Liu2012HumanSS,
  title={Human Stanniocalcin-1 Suppresses Angiotensin II-Induced Superoxide Generation in Cardiomyocytes through UCP3-Mediated Anti-Oxidant Pathway},
  author={Dajun Liu and Luping Z. Huang and Yanlin Wang and Wei Wang and Xander H T Wehrens and Tatiana Belousova and Maen Abdelrahim and Gabriel DiMattia and David Sheikh-Hamad},
  booktitle={PloS one},
  year={2012}
}
RATIONALE We have previously shown increased cardiac stanniocalcin-1 (STC1) in patients with idiopathic dilated cardiomyopathy. STC1 localizes to the inner mitochondrial membrane and transgenic over-expression of STC1 is associated with increased energy utilization. OBJECTIVE We examined the hypothesis that STC1 uncouples mitochondrial oxidative phosphorylation--to suppress superoxide generation and modulate neurohormonal effects on cardiomyocytes. METHODS AND RESULTS Compared to WT mouse… CONTINUE READING

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