Human-Specific SNP in Obesity Genes, Adrenergic Receptor Beta2 (ADRB2), Beta3 (ADRB3), and PPAR γ2 (PPARG), during Primate Evolution

@inproceedings{Takenaka2012HumanSpecificSI,
  title={Human-Specific SNP in Obesity Genes, Adrenergic Receptor Beta2 (ADRB2), Beta3 (ADRB3), and PPAR γ2 (PPARG), during Primate Evolution},
  author={Akiko Takenaka and Shin Jchi Nakamura and Fusako Mitsunaga and Miho Inoue-Murayama and Toshifumi Udono and Bambang Suryobroto},
  booktitle={PloS one},
  year={2012}
}
UNLABELLED Adrenergic-receptor beta2 (ADRB2) and beta3 (ADRB3) are obesity genes that play a key role in the regulation of energy balance by increasing lipolysis and thermogenesis. The Glu27 allele in ADRB2 and the Arg64 allele in ADRB3 are associated with abdominal obesity and early onset of non-insulin-dependent diabetes mellitus (NIDDM) in many ethnic groups. Peroxisome proliferator-activated receptor γ (PPARG) is required for adipocyte differentiation. Pro12Ala mutation decreases PPARG… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 93 references

The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes.

Biochemical and biophysical research communications • 2000
View 7 Excerpts
Highly Influenced

Dmanisi and dispersal

L Gabunia, SC Antón, D Lordkipanidze, A Vekua, A Justus
Evol Anthropol • 2001
View 15 Excerpts
Highly Influenced

Systematic assessment of a maxilla of Homo from Hadar, Ethiopia.

American journal of physical anthropology • 1997
View 15 Excerpts
Highly Influenced

Age of the earliest known hominids in Java, Indonesia.

Science • 1994
View 15 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…