Human-Specific SNP in Obesity Genes, Adrenergic Receptor Beta2 (ADRB2), Beta3 (ADRB3), and PPAR γ2 (PPARG), during Primate Evolution

@article{Takenaka2012HumanSpecificSI,
  title={Human-Specific SNP in Obesity Genes, Adrenergic Receptor Beta2 (ADRB2), Beta3 (ADRB3), and PPAR γ2 (PPARG), during Primate Evolution},
  author={A. Takenaka and Shin Jchi Nakamura and F. Mitsunaga and M. Inoue-Murayama and T. Udono and B. Suryobroto},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
  • A. Takenaka, Shin Jchi Nakamura, +3 authors B. Suryobroto
  • Published 2012
  • Medicine, Biology
  • PLoS ONE
  • Adrenergic-receptor beta2 (ADRB2) and beta3 (ADRB3) are obesity genes that play a key role in the regulation of energy balance by increasing lipolysis and thermogenesis. The Glu27 allele in ADRB2 and the Arg64 allele in ADRB3 are associated with abdominal obesity and early onset of non-insulin-dependent diabetes mellitus (NIDDM) in many ethnic groups. Peroxisome proliferator-activated receptor γ (PPARG) is required for adipocyte differentiation. Pro12Ala mutation decreases PPARG activity and… CONTINUE READING
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