Human Scavenger Receptor B1 Is Involved in Recognition of Apoptotic Thymocytes by Thymic Nurse Cells

@article{Imachi2000HumanSR,
  title={Human Scavenger Receptor B1 Is Involved in Recognition of Apoptotic Thymocytes by Thymic Nurse Cells},
  author={Hitomi Imachi and Koji Murao and C. Hiramine and Yositaka Sayo and Makoto Sato and Hitoshi Hosokawa and Toshihiko Ishida and Tatsuhiko Kodama and Oswald Quehenberger and Daniel Steinberg and Jiro Takahara},
  journal={Laboratory Investigation},
  year={2000},
  volume={80},
  pages={263-270}
}
Recognition and uptake of apoptotic cells by neighboring phagocytes is essential for the clearance of dying cells without accompanying inflammation or tissue damage. In the thymus, many apoptotic cells are generated in the process of negative selection, and both thymic macrophages (professional phagocytes) and nursing thymic epithelial cells (nursing TEC; nonprofessional phagocytes) recognize and ingest them. However the receptors responsible for this recognition and uptake have not been… CONTINUE READING
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