Human ScFv that block sodium ion channel activity of tetrodotoxin.

  title={Human ScFv that block sodium ion channel activity of tetrodotoxin.},
  author={Monrat Chulanetra and Kunan Bangphoomi and Nitat Sookrung and Jeeraphong Thanongsaksrikul and Potjanee Srimanote and Yuwaporn Sakolvarvaree and Kiattawee Choowongkomon and Wanpen Chaicumpa},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={59 2},
Tetrodotoxin (TTX) is a heterocyclic guanidinium alkaloid (C11H17N3O8) with molecular mass of ∼320 Da. The TTX and toxic analogs block sodium ion activity of mammalian nerve cells resulting in failure to conduct nerve impulse which manifested clinically in host as variable degrees of organ paralysis. Human intoxication occurs after consuming food containing the toxins. Current treatment of the poisoning is supportive and symptomatic. There has been no specific drug or antidote for the TTX… CONTINUE READING