Human STELLAR, NANOG, and GDF3 Genes Are Expressed in Pluripotent Cells and Map to Chromosome 12p13, a Hotspot for Teratocarcinoma

@article{Clark2004HumanSN,
  title={Human STELLAR, NANOG, and GDF3 Genes Are Expressed in Pluripotent Cells and Map to Chromosome 12p13, a Hotspot for Teratocarcinoma},
  author={A. Clark and Ryan T Rodriguez and M. Bodnar and M. Abeyta and M. Cedars and P. Turek and M. Firpo and R. R. Reijo Pera},
  journal={STEM CELLS},
  year={2004},
  volume={22}
}
Genes required to maintain pluripotency in human embryonic stem (hES) cells are largely unknown, with the exception of OCT‐4, a homolog of mouse Oct‐4, which is critical for the establishment of the embryonic inner cell mass and the generation of totipotent mouse embryonic stem (mES) cell lines. In the current study, we identified two genes with expression similar to OCT‐4, in that they are largely restricted to pluripotent hES cells, premeiotic germ lineage cells, and testicular germ cell… Expand
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Nanog is a critical factor underlying pluripotency in both ICM and ES cells, and it is found that one of them, encoding the homeoprotein Nanog, was capable of maintaining ES cell self-renewal independently of LIF/Stat3. Expand
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