Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.

@article{Eissenberg2005HumanSA,
  title={Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.},
  author={Joel C. Eissenberg and Madeline Y Wong and John C. Chrivia},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 15},
  pages={
          6559-69
        }
}
The putative ATPase chromatin-remodeling machine SRCAP was identified in a yeast two-hybrid protein screen by interaction with the histone acetylase CBP. SRCAP is implicated in the transcriptional coactivation of cyclic AMP- and steroid-dependent promoters, but no natural chromosomal targets for SRCAP regulation have been identified. DOM is the unique SRCAP homolog in Drosophila melanogaster. The goal of this study was to test whether SRCAP is a functional homolog of DOM and to identify… CONTINUE READING
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