Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells.

@article{Sampath2003HumanSA,
  title={Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells.},
  author={Janardhan Sampath and Pandy R Long and Robert L. Shepard and Xiaoling Xia and Viswanath Devanarayan and George Earl Sandusky and William L. Perry and Anne H. Dantzig and Mark J. Williamson and Mark W Rolfe and Robert E. Moore},
  journal={The American journal of pathology},
  year={2003},
  volume={163 5},
  pages={1781-90}
}
Our effort to identify novel drug-resistant genes in cyclophosphamide-resistant EMT6 mouse mammary tumors led us to the identification of SPF45. Simultaneously, other groups identified SPF45 as a component of the spliceosome that is involved in alternative splicing. We isolated the human homologue and examined the normal human tissue expression, tumor expression, and the phenotype caused by overexpression of human SPF45. Our analyses revealed that SPF45 is expressed in many, but not all, normal… CONTINUE READING
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