Human SOD1-G93A specific distribution evidenced in murine brain of a transgenic model for amyotrophic lateral sclerosis by MALDI imaging mass spectrometry.

@article{Acquadro2014HumanSS,
  title={Human SOD1-G93A specific distribution evidenced in murine brain of a transgenic model for amyotrophic lateral sclerosis by MALDI imaging mass spectrometry.},
  author={Elena Acquadro and Ilaria Caron and Massimo Tortarolo and Enrico M. Bucci and Caterina Bendotti and Davide Corpillo},
  journal={Journal of proteome research},
  year={2014},
  volume={13 4},
  pages={1800-9}
}
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease caused by the degeneration of motor neurons. The transgenic mouse model carrying the human SOD1G93A mutant gene (hSOD1G93A mouse) represents one of the most reliable and widely used model of this pathology. In the present work, the innovative technique of matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) was applied in the study of pathological alterations at the level of… CONTINUE READING
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