Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.

@article{Dvalos2012HumanSP,
  title={Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.},
  author={Ver{\'o}nica D{\'a}valos and Lucia Suarez-Lopez and Julio Casta{\~n}o and Anthea J. Messent and Ibane Abasolo and Yolanda Fern{\'a}ndez and Angel Guerra-Moreno and E. Martinez Esp{\'i}n and Manel Armengol and Eva Musul{\'e}n and Aurelio Ariza and Joan Say{\'o}s and Diego Arango and Sim{\'o} Schwartz},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 52},
  pages={43472-81}
}
Human SMC2 is part of the condensin complex, which is responsible for tightly packaging replicated genomic DNA prior to segregation into daughter cells. Engagement of the WNT signaling pathway is known to have a mitogenic effect on cells, but relatively little is known about WNT interaction with mitotic structural organizer proteins. In this work, we described the novel transcriptional regulation of SMC2 protein by direct binding of the β-catenin·TCF4 transcription factor to the SMC2 promoter… CONTINUE READING
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…