Human SMC 5 / 6 complex promotes sister chromatid homologous recombination by recruiting the SMC 1 / 3 cohesin complex to double-strand breaks

@inproceedings{Potts2006HumanS5,
  title={Human SMC 5 / 6 complex promotes sister chromatid homologous recombination by recruiting the SMC 1 / 3 cohesin complex to double-strand breaks},
  author={Patrick Ryan Potts and Matthew H Porteus and Hongtao Yu},
  year={2006}
}
The structural maintenance of chromosomes (SMC) family of proteins has been implicated in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). The SMC1/3 cohesin complex is thought to promote HR by maintaining the close proximity of sister chromatids at DSBs. The SMC5/6 complex is also required for DNA repair, but the mechanism by which it accomplishes this is unclear. Here, we show that RNAi-mediated knockdown of the SMC5/6 complex components in human cells increases… CONTINUE READING
14 Citations
53 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Similar Papers

Loading similar papers…