Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada syndrome.

@article{Rook1999HumanSG,
  title={Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada syndrome.},
  author={Martin B. Rook and C Bezzina Alshinawi and W Antoinette Groenewegen and Isabelle Van Gelder and Antoni CG van Ginneken and Habo J. Jongsma and Marcel M. A. M. Mannens and Arthur A. M. Wilde},
  journal={Cardiovascular research},
  year={1999},
  volume={44 3},
  pages={507-17}
}
BACKGROUND Primary dysrhythmias other than those associated with the long QT syndrome, are increasingly recognized. One of these are represented by patients with a history of resuscitation from cardiac arrest but without any structural heart disease. These patients exhibit a distinct electrocardiographic (ECG) pattern consisting of a persistent ST-segment elevation in the right precordial leads often but not always accompanied by a right bundle branch block (Brugada syndrome). This syndrome is… CONTINUE READING

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