Human S100A12: a novel key player in inflammation?

  title={Human S100A12: a novel key player in inflammation?},
  author={Jens Pietzsch and Susan Hoppmann},
  journal={Amino Acids},
S100A12 is a member of the S100 family of EF-hand calcium-binding proteins. Human S100A12 is predominantly expressed and secreted by neutrophil granulocytes and, therefore, has been assigned to the S100 protein subfamily of calgranulins or myeloid-related proteins. Intracellular S100A12 exists as an anti-parallel homodimer and upon calcium-dependent activation interacts with target proteins to regulate cellular functions. Extracellular S100A12 exists majorily as homodimer and hexamer… CONTINUE READING
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