Human Response to Repeated Low-Dose d-Amphetamine: Evidence for Behavioral Enhancement and Tolerance

@article{Strakowski2001HumanRT,
  title={Human Response to Repeated Low-Dose d-Amphetamine: Evidence for Behavioral Enhancement and Tolerance},
  author={Stephen M Strakowski and Kenji W Sax and Helen Rosenberg and Melissa P. Delbello and Caleb M. Adler},
  journal={Neuropsychopharmacology},
  year={2001},
  volume={25},
  pages={548-554}
}
Previously, we reported progressively greater behavioral responses to repeated d-amphetamine in human subjects that represented a potential model of behavioral sensitization. To extend this work, 59 healthy volunteers were randomly assigned to one of three protocols: (1) placebo administered on days 1, 3, and 5 (PPP); (2) placebo administered on days 1 and 3, and d-amphetamine (0.25 mg/kg) on day 5 (PPA); and (3) d-amphetamine administered on days 1, 3, and 5 (AAA). Comparisons were made among… CONTINUE READING

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