Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function

@article{Ristic2005HumanRF,
  title={Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function},
  author={D. Ristic and Mauro Modesti and Thijn van der Heijden and John van Noort and Cees Dekker and Roland Kanaar and C. Wyman},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={3292 - 3302}
}
Recombinase proteins assembled into helical filaments on DNA are believed to be the catalytic core of homologous recombination. The assembly, disassembly and dynamic rearrangements of this structure must drive the DNA strand exchange reactions of homologous recombination. The sensitivity of eukaryotic recombinase activity to reaction conditions in vitro suggests that the status of bound nucleotide cofactors is important for function and possibly for filament structure. We analyzed nucleoprotein… CONTINUE READING

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