Human Rad51 amino acid residues required for Rad52 binding.

  title={Human Rad51 amino acid residues required for Rad52 binding.},
  author={Hitoshi Kurumizaka and Hideki Aihara and Wataru Kagawa and Takehiko Shibata and Shigeyuki Yokoyama},
  journal={Journal of molecular biology},
  volume={291 3},
The Rad51 protein, a homologue of the bacterial RecA protein, is an essential factor for both meiotic and mitotic recombination. The N-terminal domain of the human Rad51 protein (HsRad51) directly interacts with DNA. Based on a yeast two-hybrid analysis, it has been reported that the N-terminal region of the Saccharomyces cerevisiae Rad51 protein binds Rad52;S. cerevisiae Rad51 and Rad52 both activate the homologous pairing and strand exchange reactions. Here, we show that the HsRad51 N… CONTINUE READING
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