Human Rab small GTPase- and class V myosin-mediated membrane tethering in a chemically defined reconstitution system.


Membrane tethering is a fundamental process essential for the compartmental specificity of intracellular membrane trafficking in eukaryotic cells. Rab-family small GTPases and specific sets of Rab-interacting effector proteins, including coiled-coil tethering proteins and multisubunit tethering complexes, are reported to be responsible for membrane… (More)
DOI: 10.1074/jbc.M117.811356