Human RPE expression of cell survival factors.

  title={Human RPE expression of cell survival factors.},
  author={Ping Yang and Jessica L Wiser and James J Peairs and Jessica N. Ebright and Zachary J Zavodni and Catherine Bowes Rickman and Glenn J. Jaffe},
  journal={Investigative ophthalmology & visual science},
  volume={46 5},
PURPOSE To determine basal and tumor necrosis factor (TNF)-alpha-regulated expression of retinal pigment epithelial (RPE) cell survival factors and whether regulation is dependent on nuclear transcription factor (NF)-kappaB. METHODS Cultured human RPE cells were infected with adenovirus encoding either mutant inhibitory (I)-kappaB or beta-galactosidase and treated with TNF-alpha for various times. Freshly prepared RPE/choroid and RPE samples were isolated from human donor eyes. Real-time… CONTINUE READING
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