Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks

@inproceedings{Parvathaneni2013HumanRI,
  title={Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks},
  author={Swetha Parvathaneni and Alexei Stortchevoi and Joshua A. Sommers and Robert M. Brosh and Sudha Sharma},
  booktitle={PloS one},
  year={2013}
}
Genomic instability is a known precursor to cancer and aging. The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in maintaining genome stability in all living organisms. Human RecQ homologs include RECQ1, BLM, WRN, RECQ4, and RECQ5β, three of which have been linked to diseases with elevated risk of cancer and growth defects (Bloom Syndrome and Rothmund-Thomson Syndrome) or premature aging (Werner Syndrome). RECQ1, the first RecQ helicase discovered and… CONTINUE READING

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