Human RAS superfamily proteins and related GTPases.

  title={Human RAS superfamily proteins and related GTPases.},
  author={John Colicelli},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2004 250},
  • John Colicelli
  • Published 2004 in
    Science's STKE : signal transduction knowledge…
The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger family of at least 35 related human proteins. Using a somewhat broader definition of sequence similarity reveals a more extended superfamily of more than 170 RAS-related proteins. The RAS superfamily of GTP (guanosine triphosphate) hydrolysis-coupled signal transduction relay proteins can be subclassified into RAS, RHO, RAB, and ARF families, as well as the closely related Galpha family. The members of each family… CONTINUE READING
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