Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21.

@article{Yin2004HumanRC,
  title={Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21.},
  author={Yuxin Yin and Aiping Zhu and Y Jenny Jin and Yu-Xin Liu and Xia Zhang and Kevin M. Hopkins and Howard B. Lieberman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 24},
  pages={8864-9}
}
When human cells incur DNA damage, two fundamental responses can follow, cell cycle arrest or apoptosis. Human RAD9 (hRAD9) and p53 function in both processes, but the mechanistic relationship between their activities is unknown. p53 mediates checkpoint control at G(1) by transcriptional regulation of p21. In this report, we show that hRAD9, like p53, can also regulate p21 at the transcriptional level. We demonstrate that overexpression of hRAD9 leads to increased p21 RNA and encoded protein… CONTINUE READING
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