Human RAD52 interactions with replication protein A and the RAD51 presynaptic complex.

Abstract

Rad52 is a highly conserved protein involved in the repair of DNA damage. Human RAD52 has been shown to mediate single-stranded DNA (ssDNA) and is synthetic lethal with mutations in other key recombination proteins. For this study, we used single-molecule imaging and ssDNA curtains to examine the binding interactions of human RAD52 with replication protein… (More)
DOI: 10.1074/jbc.M117.794545

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