Human PrimPol activity is enhanced by RPA

  title={Human PrimPol activity is enhanced by RPA},
  author={Mar{\'i}a I. Mart{\'i}nez-Jim{\'e}nez and Antonio Lahera and Luis Blanco},
  booktitle={Scientific Reports},
Human PrimPol is a primase belonging to the AEP superfamily with the unique ability to synthesize DNA primers de novo, and a non-processive DNA polymerase able to bypass certain DNA lesions. PrimPol facilitates both mitochondrial and nuclear replication fork progression either acting as a conventional TLS polymerase, or repriming downstream of blocking lesions. In vivo assays have shown that PrimPol is rapidly recruited to sites of DNA damage by interaction with the human replication protein A… CONTINUE READING
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Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

  • O Rechkoblit
  • Sci Adv 2, e1601317–e1601317,
  • 2016

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