Human Platelets Secrete Chemotactic Activity for Eosinophils

  title={Human Platelets Secrete Chemotactic Activity for Eosinophils},
  author={R. Charu and B. P.L.},
Thrombin-stimulated platelets liberate factors that induce chemotaxis of eosinophils and raise their cytosolic Ca2+ content ([Ca2+],). The sources of this activity are the denseand a-granules because inhibition of prostaglandin endoperoxide/thromboxane A2 formation and the platelet-activating factor receptor-antagonist WEB 2086 have no effect. Platelets from patients with Storage-Pool Deficiency show about 60% of the normal chemotactic activity with little effect on [Ca2+],, whereas completely… CONTINUE READING