Human Placenta Thioredoxin Reductase

  title={Human Placenta Thioredoxin Reductase},
  author={Stephan Gromer and L. David Arscott and Charles H. Williams and R. Heiner Schirmer and Katja Becker},
  journal={The Journal of Biological Chemistry},
  pages={20096 - 20101}
Human thioredoxin reductase is a pyridine nucleotide-disulfide oxidoreductase closely related to glutathione reductase but differing from the latter in having a Cys-SeCys (selenocysteine) sequence as an additional redox center. Because selenoproteins cannot be expressed yet in heterologous systems, we optimized the purification of the protein from placenta with respect to final yield (1–2 mg from one placenta), specific activity (42 units/mg), and selenium content (0.94 ± 0.03 mol/mol subunit… 

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