Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication

@inproceedings{Cherrier2011HumanPhosphateBindingProteinIH,
  title={Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication},
  author={Thomas Cherrier and Mikael Elias and Alicia Jeudy and Guillaume Gotthard and Valentin Le Douce and Houda Hallay and Patrick Masson and Andrea Janossy and Ermanno Candolfi and Olivier Rohr and Eric Chabri{\`e}re and Christian Schwartz},
  booktitle={Virology Journal},
  year={2011}
}
The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in naïve and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and… CONTINUE READING
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