Human Pharmacology of the methamphetamine stereoisomers

@article{Mendelson2006HumanPO,
  title={Human Pharmacology of the methamphetamine stereoisomers},
  author={John E. Mendelson and Naoto Uemura and Debra S. Harris and Rajneesh P. Nath and E. Jovell Fern{\'a}ndez and Peyton Jacob and E. Thomas Everhart and Reese T. Jones},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2006},
  volume={80}
}

Methamphetamine‐related cardiovascular diseases

TLDR
This review summarizes the current literature on the effects of MA on the cardiovascular system and concludes that abuse of crystal methamphetamine poses a growing problem for health services worldwide.

Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment

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An overview of clinical manifestations of METH neurotoxicity to the central nervous system and neurobiology underlying the consequences of administration of neurotoxic METH doses is provided, and implications of Meth neurotoxicity for treatment of human abusers of the drug are discussed.

Study of the toxicological interactions between amphetamine designer drugs in the context of polydrug abuse

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The impact of hyperthermia on the toxicity of amphetaminic mixtures and its applications in clinical practice and animal studies is investigated.

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Results clearly indicate that differential psychomotor efficacies of methamphetamine enantiomers are independent of their pharmacokinetic profiles.

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TLDR
Changing trends in methamphetamine use and problems that arise diagnostically in medico-legal cases are examined, as well as the possible effects on physical and psychological behaviours and the possible contribution of the drug to a lethal episode.

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TLDR
Inhaled l-methamphetamine delivered from a non-prescription product produced minimal effects but may be a cardiodepressant.

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TLDR
Withdrawal of METH for 2 days efficiently restored all but a few metabolites to baseline, including serum creatinine, citrate, 2-ketoglutarate, and urinary lactate, and they may be used to facilitate the diagnosis of Meth abuse.

Impact of distinct chemical structures for the development of a methamphetamine vaccine.

TLDR
The systematic generation of a series of haptens designed to target the most stable conformations of methamphetamine as determined by molecular modeling is reported, which represents a unique approach to the design of new vaccines against methamphetamine abuse.

Determination of the stereoisomeric distribution of R-( (cid:0) )- and S-( + )-methamphetamine in Thai pills in the legal context of “ not inconsiderable quantities" Regulatory Toxicology and Pharmacology

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The analyses revealed that the single value for a “ not inconsiderable quantity ” in Switzerland seems outdated, and most of the sized pills showed a much higher concentration of the more potent S-( + )-meth-amphetamine.
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TLDR
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