Human Pharmacology of the methamphetamine stereoisomers

  title={Human Pharmacology of the methamphetamine stereoisomers},
  author={John E. Mendelson and Naoto Uemura and Debra S. Harris and Rajneesh P. Nath and E. Jovell Fern{\'a}ndez and Peyton Jacob and E. Thomas Everhart and Reese T. Jones},
  journal={Clinical Pharmacology \& Therapeutics},

Methamphetamine‐related cardiovascular diseases

This review summarizes the current literature on the effects of MA on the cardiovascular system and concludes that abuse of crystal methamphetamine poses a growing problem for health services worldwide.

Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment

An overview of clinical manifestations of METH neurotoxicity to the central nervous system and neurobiology underlying the consequences of administration of neurotoxic METH doses is provided, and implications of Meth neurotoxicity for treatment of human abusers of the drug are discussed.

Study of the toxicological interactions between amphetamine designer drugs in the context of polydrug abuse

The impact of hyperthermia on the toxicity of amphetaminic mixtures and its applications in clinical practice and animal studies is investigated.

Psychomotor effect differences between l-methamphetamine and d-methamphetamine are independent of murine plasma and brain pharmacokinetics profiles

Results clearly indicate that differential psychomotor efficacies of methamphetamine enantiomers are independent of their pharmacokinetic profiles.

Methamphetamine deaths: Changing trends and diagnostic issues

Changing trends in methamphetamine use and problems that arise diagnostically in medico-legal cases are examined, as well as the possible effects on physical and psychological behaviours and the possible contribution of the drug to a lethal episode.

The Clinical Pharmacology of Intranasal l-Methamphetamine

Inhaled l-methamphetamine delivered from a non-prescription product produced minimal effects but may be a cardiodepressant.

The metabolic impact of methamphetamine on the systemic metabolism of rats and potential markers of methamphetamine abuse.

Withdrawal of METH for 2 days efficiently restored all but a few metabolites to baseline, including serum creatinine, citrate, 2-ketoglutarate, and urinary lactate, and they may be used to facilitate the diagnosis of Meth abuse.

Impact of distinct chemical structures for the development of a methamphetamine vaccine.

The systematic generation of a series of haptens designed to target the most stable conformations of methamphetamine as determined by molecular modeling is reported, which represents a unique approach to the design of new vaccines against methamphetamine abuse.

Determination of the stereoisomeric distribution of R-( (cid:0) )- and S-( + )-methamphetamine in Thai pills in the legal context of “ not inconsiderable quantities" Regulatory Toxicology and Pharmacology

The analyses revealed that the single value for a “ not inconsiderable quantity ” in Switzerland seems outdated, and most of the sized pills showed a much higher concentration of the more potent S-( + )-meth-amphetamine.



The bioavailability of intranasal and smoked methamphetamine

Methamphetamine and ethanol interactions in humans

Determination of therapeutic blood levels of methamphetamine and pentobarbital by GC.

The trichloroacetamide derivative of methamphetamine has higher electron-capture sensitivity and is more easily chromatographed than previously reported derivatives.


The study of differences in human metabolism of methamphetamine enantiomers using simple and rapid capillary zone electrophoresis method with cyclodextrin derivative as a chiral agent is reported.

Pharmacokinetic studies with amphetamines-relationship to neuropsychiatric disorders

The intensity of the psychosis in patients having an alkaline urine appeared to be dependent on the metabolite levels rather than on the plasma levels of unchanged drug, and it was found that this metabolite was eliminated slower than the parent compound.

Monoamine transporters and psychostimulant drugs.

Disposition of methamphetamine and its metabolite amphetamine in brain and other tissues in rats after intravenous administration.

Analysis of the area under the concentration-time curve molar amounts of (+)-AMP and (+)-METH showed that (+-AMP accounted for approximately one-third of the drug tissue exposure over time, indicating the importance of both (+-METH and (-)-AMP in pharmacological effects following i.v. dosing.

Clinical effects of daily methamphetamine administration.

The findings indicate that the disposition of methamphetamine and its subjective effects were not altered by this period of daily exposure to a low dose of the drug, and tolerance to the heart-rate accelerating effect was observed.

Methamphetamine - Effects on Human Performance and Behavior.

  • B. Logan
  • Psychology
    Forensic science review
  • 2002
It is concluded that the use of methamphetamine in anything other than low-dose, therapeutic administration with medical oversight raises the likelihood of some impairment of performance in complex psychomotor tasks such as driving.