Human Pharmacology of the methamphetamine stereoisomers

@article{Mendelson2006HumanPO,
  title={Human Pharmacology of the methamphetamine stereoisomers},
  author={John E. Mendelson and Naoto Uemura and Debra S. Harris and Rajneesh P. Nath and E. Jovell Fern{\'a}ndez and Peyton Jacob and E. Thomas Everhart and Reese T. Jones},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2006},
  volume={80}
}

Methamphetamine‐related cardiovascular diseases

This review summarizes the current literature on the effects of MA on the cardiovascular system and concludes that abuse of crystal methamphetamine poses a growing problem for health services worldwide.

Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment

An overview of clinical manifestations of METH neurotoxicity to the central nervous system and neurobiology underlying the consequences of administration of neurotoxic METH doses is provided, and implications of Meth neurotoxicity for treatment of human abusers of the drug are discussed.

Study of the toxicological interactions between amphetamine designer drugs in the context of polydrug abuse

The impact of hyperthermia on the toxicity of amphetaminic mixtures and its applications in clinical practice and animal studies is investigated.

Psychomotor effect differences between l-methamphetamine and d-methamphetamine are independent of murine plasma and brain pharmacokinetics profiles

Results clearly indicate that differential psychomotor efficacies of methamphetamine enantiomers are independent of their pharmacokinetic profiles.

PSYCHOPHARMACOLOGY

This study investigates the effects of maternal prenatal cannabis use on infant neurobehavior and withdrawal, infant stress response, and epigenetic regulation of placenta endocannabinoid and glucocorticoid mediators.

Methamphetamine deaths: Changing trends and diagnostic issues

Changing trends in methamphetamine use and problems that arise diagnostically in medico-legal cases are examined, as well as the possible effects on physical and psychological behaviours and the possible contribution of the drug to a lethal episode.

The Clinical Pharmacology of Intranasal l-Methamphetamine

Inhaled l-methamphetamine delivered from a non-prescription product produced minimal effects but may be a cardiodepressant.

Stereoselectivity in the human metabolism of methamphetamine.

The metabolism of MA is enantioselective, with formation of AMP having the highest isomer selectivity and the formation of pOH-MA was less affected by the MA enantiomer administered, suggesting that urine p OH-MA may be a more stable biomarker of MA metabolism.

The metabolic impact of methamphetamine on the systemic metabolism of rats and potential markers of methamphetamine abuse.

Withdrawal of METH for 2 days efficiently restored all but a few metabolites to baseline, including serum creatinine, citrate, 2-ketoglutarate, and urinary lactate, and they may be used to facilitate the diagnosis of Meth abuse.

High specific activity (+)‐amphetamine and (+)‐methamphetamine

High specific activity (+)-amphetamine and (+)-methamphetamine were prepared by reductive dechlorination of (S)-(3′,5′-dichlorophenyl)-2-propylazide and (S-2′6′- dichloromethamphetamine, respectively by stereospecific total synthesis following methodology that had been previously developed in the Laboratories.
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