Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics

  title={Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics},
  author={Jordi Riba and Marta Valle and Gloria Urbano and Mercedes Yritia and Adelaida Morte and Manel J. Barbanoj},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={73 - 83}
  • J. RibaM. Valle M. Barbanoj
  • Published 1 July 2003
  • Medicine, Biology
  • Journal of Pharmacology and Experimental Therapeutics
The effects of the South American psychotropic beverage ayahuasca on subjective and cardiovascular variables and urine monoamine metabolite excretion were evaluated, together with the drug's pharmacokinetic profile, in a double-blind placebo-controlled clinical trial. [] Key Method Eighteen volunteers with prior experience in the use of psychedelics received single oral doses of encapsulated freeze-dried ayahuasca (0.6 and 0.85 mg of DMT/kg of body weight) and placebo. Ayahuasca produced significant…

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