Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics

  title={Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics},
  author={J. Riba and Marta Valle and G. Urbano and M. Yritia and A. Morte and M. Barbanoj},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={73 - 83}
  • J. Riba, Marta Valle, +3 authors M. Barbanoj
  • Published 2003
  • Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • The effects of the South American psychotropic beverage ayahuasca on subjective and cardiovascular variables and urine monoamine metabolite excretion were evaluated, together with the drug's pharmacokinetic profile, in a double-blind placebo-controlled clinical trial. [...] Key Method Eighteen volunteers with prior experience in the use of psychedelics received single oral doses of encapsulated freeze-dried ayahuasca (0.6 and 0.85 mg of DMT/kg of body weight) and placebo. Ayahuasca produced significant…Expand Abstract
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    Publications referenced by this paper.
    Subjective effects and tolerability of the South American psychoactive beverage Ayahuasca in healthy volunteers
    • 175
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    Pharmacokinetics of Hoasca alkaloids in healthy humans.
    • 213
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    Cardiovascular and neuroendocrine effects and pharmacokinetics of 3, 4-methylenedioxymethamphetamine in humans.
    • 313
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    Human pharmacology of 3,4-methylenedioxymethamphetamine ("ecstasy"): psychomotor performance and subjective effects.
    • 213
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    Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and beta-carboline constituents of ayahuasca.
    • 262
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    Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca.
    • 129
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    Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale.
    • 262
    • Highly Influential
    • PDF