Human Papillomavirus Is Present in Some Cases of Childhood Penile Lichen Sclerosus: An In Situ Hybridization and SP‐PCR Study

@article{Drut1998HumanPI,
  title={Human Papillomavirus Is Present in Some Cases of Childhood Penile Lichen Sclerosus: An In Situ Hybridization and SP‐PCR Study},
  author={Ricardo Drut and M. A. G{\'o}mez and Ricardo Drut and M M Lojo},
  journal={Pediatric Dermatology},
  year={1998},
  volume={15}
}
Abstract: Lichen sclerosus (LS) is a skin disease that may affect both sexes at all ages and at any site. Its etiology remains unknown. The observation of focal koilocytotic‐like changes in the stratum malpighii in prepuce samples of LS in children prompted us to investigate the presence of HPV‐DNA. Twenty‐three paraffin‐embedded samples of LS lesions from children aged 4 to 14 years were studied using nested‐PCR and in situ hybridization (ISH). Twelve out of 23 cases amplified HPV‐DNA (8 cases… Expand
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