Human Papillomavirus 16 / 18 E 6 Oncoprotein Is Expressed in Lung Cancer and Related with p 53 Inactivation

@inproceedings{Cheng2007HumanP1,
  title={Human Papillomavirus 16 / 18 E 6 Oncoprotein Is Expressed in Lung Cancer and Related with p 53 Inactivation},
  author={Ya-Wen Cheng and Ming-Fang Wu and John Wang and K L Yeh and Y G Goan and Hui-Ling Chiou and Chih-Yi Chen and Huei Lee},
  year={2007}
}
Inactivation of p53 by human papillomavirus 16/18 E6 plays a crucial role in cervical tumorigenesis. To investigate the involvement of HPV16/18 in lung tumorigenesis, the association between HPV16 or HPV18 E6 and p53 protein expression in 122 lung tumors was evaluated by immunohistochemistry, and data showed that HPV16/18 E6 expression correlated inversely with p53 expression, which was further confirmed by tissue in situ immunostaining. Real-time reverse transcription-PCR analysis indicated… CONTINUE READING