Human Papillomavirus: Changing Paradigms in Oropharyngeal Cancer

  title={Human Papillomavirus: Changing Paradigms in Oropharyngeal Cancer},
  author={David J. Adelstein and Cristina P Rodriguez},
  journal={Current Oncology Reports},
The human papillomavirus (HPV) has recently been identified as an important etiologic agent in the development of squamous cell carcinoma of the oropharynx. The HPV- associated cancers appear to have a different biology than the HPV-negative cancers, and affect a population that is more likely to be young, male, Caucasian, and nonsmoking. More importantly, however, is the recognition that patients with an HPV-associated oropharyngeal cancer have a distinctly better survival after treatment than… 

The role of human papillomavirus in oral disease.

  • G. Pringle
  • Medicine, Biology
    Dental clinics of North America
  • 2014

HPV in oropharyngeal cancer: the basics to know in clinical practice

SUMMARY The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising in contrast to the decreasing incidence of carcinomas in other subsites of the head and neck, in spite of the reduced

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Asymptomatic p16-positive oropharyngeal squamous cell carcinoma: an emerging trend.

Findings underscore the importance of a comprehensive physical examination on all patients with p16-positive oropharyngeal cancer, and suggest that these patients can be treated with unimodality therapy when presenting with stage I or II disease.

Comparing Immunohistologic and Demographic Variables of Head and Neck Squamous Cell Carcinoma

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Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas

The findings demonstrate that the evaluation of CA may aid in therapeutic decision-making, and CA can serve as a promising therapeutic target for HPV-neg OPSCC patients.

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Epigenetic modifications may contribute to aberrant epigenetic mechanisms seen in oral precancers and cancers, and in the near future, epigenetic variations found in oral dysplastic cells can act as a molecular fingerprint for malignancies.



Clinical implications of human papillomavirus in head and neck cancers.

  • C. FakhryM. Gillison
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
There is sufficient evidence to conclude that a diagnosis of HPV-positive HNSCC has significant prognostic implications; these patients have at least half the risk of death from H NSCC when compared with the HPV-negative patient.

Human papillomavirus-related head and neck tumors: clinical and research implication

This review summarizes the epidemiology, clinical presentation, molecular pathogenesis, diagnosis, and therapy of HPV-associated HNSCC; it also summarizes how a better understanding of the molecular path genesis is expected to change treatment.

HPV prophylactic vaccines and the potential prevention of noncervical cancers in both men and women

Current HPV vaccines may hold great promise (provided equivalent efficacy at all relevant anatomic sites) in reducing the burden of HPV‐associated noncervical cancers, in addition to cervical cancers.

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High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma.

  • L. LicitraF. Perrone S. Pilotti
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
The molecular and clinical results are in agreement with previous findings but provide additional information into the biologic mechanisms involved in HR-HPV oropharyngeal cancer in comparison to HPV-negative tumors.

Case-control study of human papillomavirus and oropharyngeal cancer.

Oropharyngeal cancer was significantly associated with oral HPV type 16 (HPV-16) infection, and the degree of association increased with the number of vaginal-sex and oral-sex partners, among subjects with or without the established risk factors of tobacco and alcohol use.

Tissue Distribution of Human Papillomavirus 16 DNA Integration in Patients with Tonsillar Carcinoma

HPV-16 is strongly associated with carcinomas arising from the oropharynx, and integration is tightly coupled to the neoplastic process.

Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers

New evidence is shown that the prevalence of oncogenic mucosal HPV is higher in younger‐age oral cavity/oropharynx cancer cases whose sexual practices are typically associated with sexual transmission of the virus.

Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review

Tumor site–specific HPV prevalence was higher among studies from North America compared with Europe and Asia, and the high HPV16 prevalence and the lack of HPV18 in oropharyngeal compared with other HNSCCs may point to specific virus-tissue interactions.

Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States.

The proportion of OSCCs that are potentially HPV-related increased in the United States from 1973 to 2004, perhaps as a result of changing sexual behaviors.